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71.
Ming Zhao Sin Ting Lau Xiao Qi Zhang Wen Cai Ye Po Sing Leung Chun‐Tao Che Zhi‐Xiu Lin 《Helvetica chimica acta》2011,94(11):2099-2105
Bruceine K ( 1 ), a pentacyclic C20‐quassinoid bearing a unique 12,20‐epoxy moiety, and bruceine L ( 2 ), along with the ten known compounds (6S,7E)‐6,9,10‐trihydroxy‐ and (6S,7E)‐6,9‐dihydroxymegastigma‐4,7‐dien‐3‐one ( 3 and 4 , resp.), cleomiscosins A–C, luteoline, quercetine, bruceantinol, pinoresinol, and thevetiaflavone, were isolated from the ripe fruits of Brucea javanica. Bruceines K ( 1 ) and L ( 2 ) were determined to be (1β,2α,11β,12β,14ξ,15β)‐12,20‐epoxy‐1,2,11,13,14,15‐hexahydroxypicras‐3‐en‐16‐one and (1β,2α,11β,12β,15β)‐13,20‐epoxy‐1,2,11,12‐tetrahydroxy‐16‐oxo‐15‐(senecioyloxy)picras‐3‐en‐21‐oic acid methyl ester (senecioic acid=3‐methylbut‐2‐enoic acid), respectively, on the basis of NMR (1H‐ and 13C‐NMR, DEPT, 1H,1H‐COSY, NOESY, HMQC, and HMBC) and ESI‐MS data. Among the known compounds, (6S,7E)‐6,9,10‐trihydroxy‐ and (6S,7E)‐6,9‐dihydroxymegastigma‐4,7‐dien‐3‐one ( 3 and 4 , resp.), cleomiscosin C, luteoline, quercetine, and thevetiaflavone were isolated for the first time from the Brucea plants. 相似文献
72.
Anthony J. Veloso Tiffiny Chan Vinci Wing Sze Hung Leayen Lam Kagan Kerman 《Electroanalysis》2011,23(12):2753-2756
The amyloid‐β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer’s disease (AD). The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ‐binding therapeutics in a rapid and cost‐effective format. The results of the differential pulse voltammetry (DPV) measurements were confirmed using simultaneous UV‐vis analysis of the same incubated Aβ samples. The early changes in the electrochemical signals were attributed to the interaction of the Aβ oligomers with CR. The electrochemical approach, in principle, allowed monitoring small molecule‐Aβ interactions on the time scale of aggregation. 相似文献
73.
L. F. Yang Q. S. Li A. Y. T. Leung Y. L. Zhao G. Q. Li 《European Journal of Mechanics - A/Solids》2002,21(6):104
Linear and non-linear peaky fuzzy numbers and their arithmetic operations are constructed for the analysis of engineering structures with fuzzy characteristic quantities. Fuzziness of the corresponding quantities is consistently incorporated into the functional of the total potential energy. A set of deterministic recursive equations is obtained as the alternative expressions of the fuzzy variational principle by means of the second-order perturbation technique. The fuzzy Ritz method and the fuzzy finite element method are presented as the applications of the fuzzy variational principle. Accordingly, the roundabout procedures frequently used in the formulations of the fuzzy finite element method are avoided. A benchmark problem of a bending beam with fuzzy Young's modulus under fuzzy external loading is solved by the developed fuzzy numerical methods. Numerical examples show that results determined by these two fuzzy methods are both little conservative, and are in good agreement with those obtained by the analytical method. Moreover, the fuzzy Ritz method or the fuzzy finite element method can provide more valuable information than the conventional deterministic methods. 相似文献
74.
X. B. Zeng A. W. N. Leung X. S. Xia H. P. Yu D. Q. Bai J. Y. Xiang Y. Jiang C. S. Xu 《Laser Physics》2010,20(6):1500-1503
In the present study, we have successfully set up a novel blue light source with the power density of 9 mW/cm2 and the wavelength of 435.8 nm and then the novel light source was used to investigate the effect of light radiation on curcumin-induced
cell death. The cytotoxicity was investigated 24 h after the treatment of curcumin and blue light radiation together using
MTT reduction assay. Nuclear chromatin was observed using a fluorescent microscopy with Hoechst33258 staining. The results
showed blue light radiation could significantly enhance the cytotoxicity of curcumin on the MCF-7 cells and apoptosis induction.
These findings demonstrated that blue light radiation could enhance curcumin-induced cell death of breast cancer cells, suggesting
light radiation may be an efficient enhancer of curcumin in the management of breast cancer. 相似文献
75.
Nishar Hameed Qipeng Guo Tracey Hanley Yiu‐Wing Mai 《Journal of Polymer Science.Polymer Physics》2010,48(7):790-800
Hydrogen bonding interactions, phase behavior, crystallization, and surface hydrophobicity in nanostructured blend of bisphenol A‐type epoxy resin (ER), for example, diglycidyl ether of bisphenol A (DGEBA) and poly(ε‐caprolactone)‐block‐poly(dimethyl siloxane)‐block‐poly(ε‐caprolactone) (PCL–PDMS–PCL) triblock copolymer were investigated by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry, transmission electron microscopy, small‐angle X‐ray scattering, and contact angle measurements. The PCL–PDMS–PCL triblock copolymer consisted of two epoxy‐miscible PCL blocks and an epoxy‐immiscible PDMS block. The cured ER/PCL–PDMS–PCL blends showed composition‐dependent nanostructures from spherical and worm‐like microdomains to lamellar morphology. FTIR study revealed the existence of hydrogen bonding interactions between the PCL blocks and the cured epoxy, which was responsible for their miscibility. The overall crystallization rate of the PCL blocks in the blend decreased remarkably with increasing ER content, whereas the melting point was slightly depressed in the blends. The surface hydrophobicity of the cured ER increased upon addition of the block copolymer, whereas the surface free energy (γs) values decreased with increasing block copolymer concentration. The hydrophilicity of the epoxy could be reduced through blending with the PCL–PDMS–PCL block copolymer that contained a hydrophobic PDMS block. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 790–800, 2010 相似文献
76.
Yen‐Chung Chen Jonathan T. B. Huang Kee‐Ching G. Jeng Robin C. K. Yang Mo‐Kai Liao Chee‐Shan Chen Wei‐Jyun Chien Ming‐Tsair Wey Lou‐Sing Kan Leung Sheh 《中国化学会会志》2010,57(2):266-274
To study DNA allostery, quantitative DNase I footprinting studies were carried out on a newly designed peptide His‐Hyp‐Lys‐Lys‐(Py)4‐Lys‐Lys‐NH2 (HypKK‐10) containing the XHypKK (Hyp = hydroxyproline) and polyamide motifs. The interconnection of DNA footprints of peptides HypKK‐10 and the parent peptide PyPro‐12 supports the proposal that interaction network cooperativity is preferred in DNA‐peptide interactions between multiple recognition sites. A simple method of determining interstrand bidentate interactions between the peptide moieties and DNA bases is introduced. It is envisaged that interstrand bidentate interactions also participate in the relay of conformational changes to recognition sites on the complementary strands. Circular dichroism studies of the titration of peptide HypKK‐10 with an oligonucleotide duplex indicate that this peptide binds in a dimeric fashion to DNA in the minor groove. This work may prompt the design of new DNA binding ligands for the study of DNA‐peptide allosteric interactions and DNA interaction network. 相似文献
77.
Yong Mei Hu Guang Hai Su Stephen Cho‐Wing Sze Wencai Ye Yao Tong 《Biomedical chromatography : BMC》2010,24(4):438-453
A simple method based on liquid chromatography coupled with diode array detection and electrospray ionization mass spectrometry (LC‐DAD‐ESI‐MS) was developed for the quality assessment of Cortex Phellodendri (CP), which was mainly derived from two species of Phellodendron chinense Schneid and Phellodendron amurense Rupr. Total 41 compounds, including 14 phenols, 24 alkaloids and three liminoidal triterpenes were identified or tentatively characterized from the 75% methanol extract of CP samples by online ESI‐MSn fragmentation and UV spectra analysis. Among them, two phenols and six alkaloids were simultaneously quantified using HPLC‐DAD method. The validated HPLC‐DAD method showed a good linearity, precision, repeatability and accuracy for the quantification of eight marker compounds. Furthermore, the plausible fragmentation pathway of the representative compounds were proposed in the present study. The differences of the chemical constituents content and the comprehensive HPLC profiles between the two CP species using LC‐DAD‐ESI‐MS method are reported for the first time, indicating that the CP drugs from different resources should be used separately in the clinic. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
78.
Joanne Dombrowski 《Journal of Mathematical Analysis and Applications》2011,378(1):133-139
This paper uses commutator equations to study the absolute continuity of spectral measures associated with certain subclasses of unbounded self-adjoint Jacobi matrix operators determined by properties of the diagonal and subdiagonal sequences. If the diagonal sequence is the zero sequence, properties of the difference sequence of the subdiagonal determine the choice of a bounded operator for the commutator equation. The structure of the resulting commutator leads to results on absolute continuity. 相似文献
79.
Container ports are a major component of international trade and the global supply chain. Hence, the improvement of port efficiency can have a significant impact on the wider maritime economy. This paper deconstructs a representation in the existing literature that neglects the heterogeneity of individual and group-specific terminal operators. In its place, we present a hierarchical model to make a connection between efficiency and terminal operator group characteristics. The paper develops a stochastic frontier model that controls not only individual heterogeneity but also group-specific variations. The model decomposes the total stochastic derivation from the frontier into inefficiency, individual heterogeneity, group-specific variations, and noise components, with the estimation being performed using Markov chain Monte Carlo simulations. The validity of the model is tested with a panel of container terminal operator data from 1997-2004. Our findings show that terminal operator groups are important in promoting terminal efficiency at the global level, and that the operators with stevedore backgrounds show a higher efficiency than carriers. 相似文献
80.